上皮間質(zhì)轉(zhuǎn)化(EMT)4種標(biāo)志物介紹
上皮間質(zhì)轉(zhuǎn)化(epithelial-mesenchymal transition,EMT)是上皮細(xì)胞向間充質(zhì)細(xì)胞轉(zhuǎn)化的一個(gè)過程,上皮細(xì)胞失去頂基細(xì)胞極性,失去粘附性并獲得間充質(zhì)細(xì)胞的表型,獲得間充質(zhì)細(xì)胞遷移能力以促進(jìn)轉(zhuǎn)移和耐藥性。EMT常見于胚胎發(fā)育、傷口愈合、器官纖維化和腫瘤轉(zhuǎn)移。EMT和間充質(zhì)上皮轉(zhuǎn)化(mesenchymal-epithelial transition, MET)參與胚胎的早期和晚期發(fā)育,如著床、原腸胚形成、心臟發(fā)育等。EMT和MET參與了干細(xì)胞表型變化和細(xì)胞遷移的調(diào)控,是細(xì)胞差異分化和三維組織···
2024-02-05