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產(chǎn)品詳情
| 名稱： | anti- PALB2 antibody |
|---|---|
| 貨號： | FNab06125 |
| 適應(yīng)種屬： | 人源 |
| 規(guī)格： | 100ug(微克) |
| 狀態(tài)： | 液體 |
| 純化方法： | 免疫親和純化 |
| 純度： | 經(jīng)SDS-PAGE分析,純度大于95% |
| 宿主： | 兔 |
| 亞型： | lgG |
| 存儲： | 用添加了0.02%疊氮化鈉和50%甘油的PBS溶解,PH值7.3,可在-20℃下保存12個月（避免反復(fù)凍融） |
| 免疫原： | partner and localizer of BRCA2 |
| 免疫原別稱： | DKFZp667I166 antibody, DKFZp686E1054 antibody, FANCN antibody, FLJ21816 antibody, PALB2 antibody, partner and localizer of BRCA2 antibody |
| 分子量： | 131kd |
| 驗(yàn)證應(yīng)用： | ELISA, WB, IHC |
| 建議稀釋比例： | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| UniProt ID： | Q86YC2 |
| 克隆性： | 多克隆 |
| 背景介紹： | Plays a critical role in homologous recombination repair(HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A(RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated deg |
| 圖像： |  Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab06125(PALB2 Antibody) at dilution of 1:100。
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