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產(chǎn)品詳情
| 名稱： | anti- TP53 antibody |
|---|---|
| 貨號： | FNab08878 |
| 適應(yīng)種屬： | 人源,大鼠,小鼠 |
| 規(guī)格： | 100ug(微克) |
| 狀態(tài)： | 液體 |
| 純化方法： | 免疫親和純化 |
| 純度： | 經(jīng)SDS-PAGE分析,純度大于95% |
| 宿主： | 兔 |
| 亞型： | lgG |
| 存儲： | 用添加了0.02%疊氮化鈉和50%甘油的PBS溶解,PH值7.3,可在-20℃下保存12個月（避免反復(fù)凍融） |
| 免疫原： | tumor protein p53 |
| 免疫原別稱： | Cellular tumor antigen p53 antibody, FLJ92943 antibody, LFS1 antibody, P53 antibody, Phosphoprotein p53 antibody, TP53 antibody, TRP53 antibody, tumor protein p53 antibody, Tumor suppressor p53 antibody |
| 分子量： | 53 kDa |
| 驗證應(yīng)用： | ELISA, IHC, IP, WB, IF |
| 建議稀釋比例： | WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:20-1:200 |
| UniProt ID： | P04637 |
| 克隆性： | 多克隆 |
| 背景介紹： | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21(lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK c |
| 圖像： |  Immunohistochemistry of paraffin-embedded human ovary tumor tissue using FNab08878(P53 antibody) at dilution of 1:100。
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