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產(chǎn)品詳情
| 名稱： | anti- Phospho-CHEK1-S280 antibody |
|---|---|
| 貨號： | FNab09816 |
| 適應種屬： | 人源,小鼠 |
| 規(guī)格： | 100ug(微克) |
| 狀態(tài)： | 液體 |
| 純化方法： | 免疫親和純化 |
| 純度： | 經(jīng)SDS-PAGE分析,純度大于95% |
| 宿主： | 兔 |
| 亞型： | lgG |
| 存儲： | 用添加了0.02%疊氮化鈉和50%甘油的PBS溶解,PH值7.3,可在-20℃下保存12個月（避免反復凍融） |
| 免疫原： | Phospho-CHEK1-S280 |
| 免疫原別稱： | CHK1 antibody |
| 分子量： | 60 kDa |
| 驗證應用： | ELISA, WB, IHC, IF |
| 建議稀釋比例： | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200 |
| UniProt ID： | O14757 |
| 克隆性： | 多克隆 |
| 背景介紹： | The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. |
| 圖像： |  Immunofluorescence analysis of MCF-7 cells using FNab09816. Blue: DAPI for nuclear staining。
|
