服務(wù)熱線
15623758226
聯(lián)系方式
- 手機(jī)：15623758226
- 電話：027-65524773
- Q Q：3038053592
- 郵箱：3038053592@qq.com
- 地址：武漢東湖新技術(shù)開發(fā)區(qū)高新二路388號武漢光谷國際生物醫(yī)藥企業(yè)加速器1.2期C22棟一層、二層
發(fā)布時間：2023-08-30 16:03?? 咨詢量：
聯(lián)系客服 027-65524773
資料下載sales2@fn-test.com
產(chǎn)品詳情
| 名稱： | anti- Chk2 antibody |
|---|---|
| 貨號： | FNab01654 |
| 適應(yīng)種屬： | 人源,大鼠,小鼠 |
| 規(guī)格： | 100ug(微克) |
| 狀態(tài)： | 液體 |
| 純化方法： | 免疫親和純化 |
| 純度： | 經(jīng)SDS-PAGE分析,純度大于95% |
| 宿主： | 兔 |
| 亞型： | lgG |
| 存儲： | 用添加了0.02%疊氮化鈉和50%甘油的PBS溶解,PH值7.3,可在-20℃下保存12個月（避免反復(fù)凍融） |
| 免疫原： | CHK2 checkpoint homolog (S. pombe) |
| 分子量： | 70 kDa |
| 驗證應(yīng)用： | ELISA, WB, IHC, IF |
| 建議稀釋比例： | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200 |
| UniProt ID： | O96017 |
| 克隆性： | 多克隆 |
| 背景介紹： | In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarc |
| 圖像： |  Immunofluorescence analysis of A549 cells using FNab01654(Chk2 antibody) at dilution of 1:100。
|
