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名稱: | anti- LIG4 antibody |
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貨號(hào): | FNab04774 |
適應(yīng)種屬: | 人源,小鼠 |
規(guī)格: | 100ug(微克) |
狀態(tài): | 液體 |
純化方法: | 免疫親和純化 |
純度: | 經(jīng)SDS-PAGE分析,純度大于95% |
宿主: | 兔 |
亞型: | lgG |
存儲(chǔ): | 用添加了0.02%疊氮化鈉和50%甘油的PBS溶解,PH值7.3,可在-20℃下保存12個(gè)月(避免反復(fù)凍融) |
免疫原: | ligase IV, DNA, ATP-dependent |
分子量: | 100-104 kDa |
驗(yàn)證應(yīng)用: | ELISA, WB, IHC |
建議稀釋比例: | WB: 1:500-1:2000; IHC: 1:20-1:200 |
UniProt ID: | P49917 |
克隆性: | 多克隆 |
背景介紹: | Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining(NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. |
圖像: | ![]() Immunohistochemistry of paraffin-embedded human prostate cancer using FNab04774(LIG4 antibody) at dilution of 1:100。
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